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Methylation support; Homocysteine metabolism; Brain and mood support; Prenatal folate nutrition; Cardiovascular health
Adults who want a bioactive folate source or those seeking convenient daily methyl donor support.
Take 1 capsule two to three times daily; taking with meals may improve tolerance.
Gluten Free
5-MTHF is the bioactive folate form that donates methyl groups for one-carbon metabolism, supporting homocysteine remethylation, neurotransmitter synthesis, and DNA methylation.
Caution: High-dose folate may mask signs of low vitamin B12, so be mindful of B12 status; if pregnant or nursing, consult a healthcare professional due to the high potency.
Label Warning: Use only if bottle is sealed. If pregnant, consult your healthcare practitioner before using this product.
Who should be cautious: People taking high-dose folate may want to discuss use with a healthcare provider if they have a history of B12 deficiency or are on medications where folate status is a concern.
Storage: Store tightly sealed in a cool, dry place.
Many users felt more energized and clear-headed after consistent use over a few months.
Several reviewers mentioned steadier mood and perceived hormonal balance benefits.
A few reviews mentioned migraines; responses varied by individual.
This product is guaranteed authentic and backed by our easy returns & refunds policy. Details
Vitamin B12 and folate work together to support energy production and red blood cell formation, which may help maintain overall vitality and well-being.
AI generated. Not medical advice.
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Support heart health, fetal development, nervous system, and mood with 5-MTHF.
5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brain, blood, and bone health and is suitable for individuals with MTFHR gene mutations.
Take 1 capsule two to three times daily or as recommended by your health-care practitioner.
Microcrystalline cellulose, hypromellose (derived from cellulose) capsule, leucine, silicon dioxide.
Manufactured in the USA using US & imported ingredients.
Tamper Evident: Use only if bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your health-care practitioner before using this product.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.
| Supplement facts | ||
| Serving Size: One Capsule | ||
| One Capsule Contains: | %Daily Value | |
| Folate (5 mg as L-5-Methyltetrahydrofolate †) | 8.3 mg DFE | 2,075% |
| Daily Value (DV) †This product uses Gnosis S.p.A.'s L-Methyltetrahydrofolate (Extra-folate-S). | ||
